Betting Bills vs Colts Pick for 2024 NFL Week 10: Odds and Pick

As the Buffalo Bills head into their Week 10 matchup against the Indianapolis Colts, questions are mounting around their recent struggles and injury woes. Meanwhile, the Colts, currently 4-5, aim to stay competitive in the AFC wild-card race. With so much at stake, NFL game odds for this crucial AFC showdown are drawing attention from bettors eager to make informed picks. Here’s a breakdown of the odds, team form, injury impact, and betting insights for the Bills vs. Colts in Week 10.

Betting Bills vs Colts Pick for the 2024 NFL Week 10
NFL Week 10 Firestorm: Bills vs. Colts – Who Will Reign Supreme?

2024 NFL Season | 104th season of National League in the United States
Week 10: Thursday, October 31st – Monday, November 4th, 2024

Betting 2024 Buffalo Bills at Indianapolis Colts Week 10 Game

As the Buffalo Bills head into their Week 10 matchup against the Indianapolis Colts, questions are mounting around their recent struggles and injury woes.

Buffalo has won four straight games, yet confidence seems to be waning as they prepare for a road game at Lucas Oil Stadium.

Meanwhile, the Colts, currently 4-5, aim to stay competitive in the AFC wild-card race.

Here’s a breakdown of the odds, team form, injury impact, and betting insights for this crucial AFC showdown.

NFL Week 10: Buffalo Bills at Indianapolis Colts
Sunday, October 27th, 2024 at 1:00 PM EST CBS | GEHA Field at Arrowhead Stadium, Kansas City, MO

ATS Odds: Buffalo -4
Money line Odds: Bills -210, Colts +170
Over/Under Odds: 46

Writer’s Breakdown and Pick for the Bills vs Colts Game

Buffalo Bills Analysis

The Bills have cruised through their past few games, overcoming teams like the Miami Dolphins and Seattle Seahawks.

However, injuries are starting to impact their lineup.

Wide receiver Keon Coleman and defensive end Dawuane Smoot both suffered wrist injuries last week, with Smoot now on injured reserve.

These absences are notable for a team already facing challenges in both passing and rushing defenses.

Quarterback Josh Allen remains a major factor, leading an offense that has scored over 30 points in six games this NFL season.

Allen’s effectiveness will be critical, especially as the Bills attempt to work around their injury-laden defense.

With upcoming games against stronger opponents like the Kansas City Chiefs, the Bills need to secure this victory to maintain momentum in the AFC.

Indianapolis Colts Analysis

The Colts have had a mixed season but remain competitive, with all nine of their games decided by eight points or less.

Veteran quarterback Joe Flacco is expected to start again after a poor showing last week, where the team reached season-lows in points and first downs.

Flacco’s ability to rebound will be essential, especially as the Colts face a Bills team vulnerable to running attacks.

Indianapolis has consistently stayed close in games, largely due to their run game and a defense that can hold its ground against good offenses.

While Buffalo has struggled in rushing defense, the Colts have an opportunity to capitalize if they can establish an early lead.

However, their secondary faces a challenge in containing Allen and his quick passing attack.

Colts vs. Bills Betting Predictions

Buffalo’s injuries could play a significant role, especially if Coleman’s absence limits Allen’s receiving options and Smoot’s IR status weakens their pass rush.

The Bills recent betting trends indicate a decrease in confidence.

This is a pivotal moment for the Bills to regain their footing.

This game looks set to be competitive, with Buffalo’s edge riding on Josh Allen — and the Colts leaning on their ground game.

However, the Bills may struggle to cover the spread if the Colts can control the clock and limit Allen’s opportunities.

Writer’s Prediction: Bills 24, Colts 21

NFL Week 10 SU Pick: Indianapolis Colts -250

Bet the NFL Week 10 | NFL Live Betting MyBookie Betting Lines for the Games

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Buffalo at Indianapolis Betting Trends Today

Buffalo are 0-6 SU in their last 6 games when playing on the road against Indianapolis.
Buffalo are 11-3 SU in their last 14 games against an opponent in the American Football Conference conference.
The total has gone OVER in 4 of Buffalo’s last 6 games against an opponent in the American Football Conference South division.
Buffalo are 1-5 ATS in their last 6 games played in November.
Indianapolis are 6-0 ATS in their last 6 games against an opponent in the American Football Conference conference.
Indianapolis are 6-1 SU in their last 7 games against an opponent in the American Football Conference East division.
The total has gone UNDER in 4 of Indianapolis’ last 6 games played in November.
The total has gone UNDER in 6 of Indianapolis’ last 8 games played on a Sunday

Colts vs. Bills Series History

Last meeting:
Bills 15, Colts 41: November 21st, 2021: Week 11 – Highmark Stadium, Orchard Park, NY

Head-to-head (includes postseason games):
Buffalo Bills lead series 38-33-1

From @GMFB: #Chiefs WR Rashee Rice is feared to have torn his ACL; #Colts QB Anthony Richardson (hip pointer) escaped major injury; RB Jonathan Taylor has a mild high-ankle sprain. pic.twitter.com/zaCq9A0nyD
— Ian Rapoport (@RapSheet) September 30, 2024

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How to Bet Colts vs. Bills Game? Let’s Find Out

Betting on the Colts vs. Bills game is easy!

To place a bet on this exciting NFL Week 10 matchup, you’ll need to sign up with an online sportsbook that offers NFL betting.

Here’s how to get started:

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Find the Colts vs. Bills game:
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Place your bet:
Choose your preferred bet type (e.g., moneyline, point spread, over/under) and wager the desired amount.

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NFL Week 11: Colts vs Bills Betting Analysis & Prediction

Previous Betting News

Two teams fighting for a playoff spot throw down on Sunday when the Indianapolis Colts travel to Buffalo to take on the Bills. Indianapolis can’t afford to lose any more games this season. Although Buffalo is the favorite to win the Super Bowl, the Bills are just a game ahead of New England in the NFC East. Which team gets it done in NFL Week 11? See below for NFL odds, analysis, and a free pick for Colts at Bills.

NFL Betting Preview for Indianapolis Colts at Buffalo

NFL Week 11 Betting | Indianapolis Colts vs Buffalo Bill Game Odds & Info

When: Sunday, Nov. 21 at 1:00 pm ET
Where: Highmark Stadium, Orchard Park, NY
TV / Streaming: CBS / Paramount +
ATS Odds: Buffalo -7 ½
Moneyline Odds: Indianapolis +270 / Buffalo -340
Over/Under Odds: 50

Why bet on Indianapolis versus Buffalo?

The Colts have started to turn things around. Indianapolis began the season losing 4-of-5. Since then, they’ve won 4-of-5. Even though they didn’t cover the spread versus the Jaguars in Week 10, the Colts played great. Indianapolis held Trevor Lawrence and Jacksonville to 17 points in the 23-17 victory. If the Colts’ defense plays as spirited on Sunday, Indy can pull off the moneyline upset victory.

Why bet on Buffalo versus Indianapolis?

In NFL Week 9, the Bills suffered the most embarrassing loss of the season. Buffalo entered Jacksonville a -13 ½ favorite. The Bills dropped the game 9-6. Last Sunday, Buffalo didn’t wait around for the Jets to beat them. The Bills jumped all over NYJ in the 45-17 win. Now back on track, Buffalo won’t allow a team like Indianapolis to stand in their way.

Indianapolis Colts at Buffalo Bills Final Betting Prediction

The Bills did put a whupping on the New York Jets. But we shouldn’t read too much into the victory. When Buffalo has faced a tough team, they’ve struggled.

On Sunday, the number one ranked defense in the NFL faces one of the better quarterbacks in the league. Colts signal-caller Carson Wentz is having a decent season.

Wentz has thrown for 2,378 yards and 17 TDs when completing 63.5% of his passes. He’s thrown just 3 picks and has managed the Colts’ offense with ease.

Buffalo can’t just stop Wentz on Sunday. They must deal with Indy’s rushing attack, which yields 136.3 yards per. The biggest problem Buffalo has in this game is turnover ratio.

The Colts have forced 21 turnovers this season. At times, Buffalo’s offense has become stagnant. It was nonexistent against both the Steelers in Week 1 and the Jaguars in Week 10. The Colts may field the best defense the Bills have played in 2021. So it makes sense to consider backing Indy on the moneyline.

NFL Week 11 Pick: Indianapolis Colts moneyline